Agenda

2019 Southeast Regional IDeA Conference Agenda

November 6-8, 2019

Galt House Hotel
Louisville, Kentucky

DOWNLOAD AGENDA (PDF)

WEDNESDAY, NOVEMBER 6, 2019
1:00 –9:00 pm Registration Desk Hours of Operation West/Rivue Tower, 3rd Floor
2:30 - 4:30 pm Concurrent Session A
2:30 - 4:30 pm Session 1:  Bioinformatics Core Workshop – High Throughput Sequence Analysis and Lessons Learned Description

Chair
Eric Rouchka, D.Sc., Professor of Computer Engineering and Computer Science, Bioinformatics Core Director, Kentucky-IDeA Networks of Biomedical Research Excellence, University of Louisville

Introduction

Workshop Presentations

Overview of approaches for RNA-Seq analysis and evaluation of alternative methods
Eric Rouchka, D.Sc., Kentucky Biomedical Research Infrastructure Network Bioinformatics Core Director, Professor of Computer Engineering and Computer Science, University of Louisville

The pitfalls of REPL, and evolving software versions in long-running projects: two lessons learned in the WV-INBRE Bioinformatics Core Facility
James Denvir, Ph.D., WV-INBRE Bioinformatics Core Director, Associate Professor of Bioinformatics, Department of Biomedical Sciences, Marshall University

Case studies in high-throughput sequencing QA/QC and harnessing the power of visualization
Eric Rouchka, D.Sc., Kentucky Biomedical Research Infrastructure Network Bioinformatics Core Director, Professor of Computer Engineering and Computer Science, University of Louisville

Short talks 

Single-cell sequencing of the choroid-plexuses from Zika virus-infected mice revealed a potential brain entry mechanism for Zika virus
Donghoon Chung, Ph.D., Associate Professor of Microbiology, University of Louisville

Use of small RNA sequencing to examine siRNA biogenesis in a basal arthropod
Alex Flynt, PhD., Associate Professor, Molecular and Cellular Biology, University of Southern Mississippi

Flash Talks

Clustering of families of G-quadruplex sequences.
Aryan Neupane, University of Louisville. (Poster 15).

Deep learning for diabetic retinopathy detection in smartphone-based retinal images using iNview device.
Recep Hacisoftaoglu, University of Central Arkansas. (Poster 16)

DESeq Explorer: a web-based dissemination tool for results of differential gene expression experiments.
James Denvir, Marshall University. (Poster 17)

Differentially spliced genes and differentially expressed genes.
Tae Lim Kook, University of Louisville. (Poster 18)

Exploration of RNA-seq analysis pipelines.
Jonah Daneshmand, University of Louisville. (Poster 19)

Gene expression profiling in cochlea.
Jae Yeon Hwang, University of Louisville. (Poster 20)

Investigating ancient introgression between caballine and non-caballine equids.
Kalpani de Silva, University of Louisville. (Poster 21)

Modelling and molecular docking studies of the cytoplasmic domain of Wsc-family, full length Rasp2p, and therapeutic antifungal compounds.
Elsie Pares-Matos. University of Puerto – Mayaguez. (Poster 22)

Prediction of biological processes indirectly-targeted.
Mohammed Sayed, University of Louisville. (Poster 23).

Statistical approach for gene set analysis with trait specific quantitative trait loci.
Samarendra Das, University of Louisville. (Poster 24).

Time-homogeneous divergence time estimation using fossilized birth-death models in Formicidae.
Christina Kolbmann, Louisiana Biomedical Research Network. (Poster 25)

A comparison of normalization and statistical tests for differential gene expression analysis in RNA-seq studies.
Xiaohong Li, University of Louisville. (Poster 42)

Evaluation of circular RNAs in the ischemia-reperfusion injured neuronal retina.
Kalina Andreeva, University of Louisville. (Poster 80)

Beckman
2:30 - 4:30 pm Session 2:  KBRIN Electron Microscopy Core Workshop Description

Chair
Martha Bickford, PhD,  Professor of Anatomical Sciences and Neurobiology, Associate Director, Kentucky-IDeA Networks of Biomedical Research Excellence, University of Louisville
Presenters

University of Louisville - Electron Microscopy Core Facility
Martha Bickford, Ph.D., Kentucky Biomedical Research Infrastructure Network Associate Director, Professor of Anatomical Sciences and Neurobiology, University of Louisville

University of Louisville - Micro/Nano Technology Center
Julia Aebersold, Ph.D., Manager, Micro/Nano Technology Center, University of Louisville

Evgeniya Moiseeva, Ph.D., Senior Process Engineer, Micro/Nano Technology Center, University of Louisville

Jasmin Beharic, Ph.D., Senior Process Engineer, Micro/Nano Technology Center, University of Louisville

University of Kentucky - Electron Microscopy Center
John Balk, Ph.D., PE, Associate Dean for Research and Graduate Studies, William T. Bryan Professor of Materials Engineering, Director, Electron Microscopy Center, University of Kentucky

Western Kentucky University - Ogden College Electron Microscopy Facility
John Andersland, Ph.D., Director Electron Microscopy Core, Biology Department, Western Kentucky University

Taylor
 2:30 - 4:30 pm Session 3:  Community Engagement and Health Disparities  Description

Chair
Jennifer Lemacks, PhD, Mississippi INBRE Telenutrition Center
Keynote Speaker
Tammy Greer, PhD, The University of Southern Mississippi, Mississippi INBRE Telenutrition Center
Short Talks
June Gipson, PhD, EdS, My Brother’s Keeper Inc, Mississippi INBRE Community Engagement and Training Core
Michael Madson, PhD, The University of Southern Mississippi, Mississippi INBRE Telenutrition Center
Kate Stewart, MD, MPH, University of Arkansas for Medical Sciences
Michael Ramsey, BA, Jackson State University, Mississippi INBRE Telenutrition Center
Flash Talks
Xavier Sam, East Central Community College
Tatum Freeman, The University of Southern Mississippi
McCreary
3:00 pm Hotel Check-In
Rooms will be available beginning at this time; early check-in is not guaranteed
1st Floor - Suite Tower
3:00 - 11:00 pm Setup – Poster Session I, Group A Cochran Ballroom
5:30 - 8:30 pm Welcome Reception and Dinner 
– Self Guided tour of Exhibit Floors Open from 5:30 to 7:30 pm
– Dinner 6:00 to 7:30 pm
Muhammad Ali Center
View Pointe Hall
THURSDAY, NOVEMBER 7, 2019
7:00 am - 9:00 pm Registration Desk Hours of Operation West/Rivue Tower, 3rd Floor
7:00 - 9:00 am Setup – Poster Session I, Group A Cochran Ballroom
7:30 - 9:30 am
Welcome Breakfast and Presentations
Welcome
Nigel Cooper, Ph.D., Professor, Anatomical Sciences and Neurobiology, Director, Kentucky-IDeA Networks of Biomedical Research Excellence, University of Louisville
Opening Remarks
Robert S. Keynton, Ph.D., Interim Executive Vice President for Research & Innovation, Professor and Lutz Endowed Chair of Biomechanical Devices, University of Louisville
Updates from NIGMS and NIH
Judith H. Greenberg, Ph.D., Deputy Director, NIGMS, NIH
Fostering Biomedical Entrepreneurship in IDeA States via Regional Accelerator Hubs
Krishan K. Arora, Ph.D., Program Director, Division for Research Capacity Building, NIGMS, NIH
From Lab to Market - A Research Team’s Journey (Video)
Jackie Willmot, RN, MSN, MBA, CEO and Co-Founder, XLerateHealth
Archibald Ballroom
9:30 - 11:00 am Concurrent Session B
9:30 - 11:00 am Session 1:  Advances in Cancer Research Description

Chair
Nathan L. Vanderford, Ph.D., MBA, Assistant Professor, Department of Toxicology and Cancer Biology, Assistant Director for Research, Markey Cancer Center, Director of Administration, Center for Cancer and Metabolism, Director, Appalachian Career Training in Oncology Program
Keynote Speaker
A novel form of CD137 immune checkpoint stimulator as an effective agent for cancer immunoprevention.
Haval Shirwan, Ph.D., Dr. Michael and Joan Hamilton Endowed Chair in Autoimmune Disease, ICT, Professor, Department of Microbiology and Immunology, Member, James Brown Cancer Center, University of Louisville

Short talks

Role of human NAT2 acetylator polymorphism on cancer risk assessment from arylamine carcinogens
David W. Hein, Ph.D., Peter K. Knoefel Endowed Chair of Pharmacology, Professor and Chair, Department of Pharmacology & Toxicology, Distinguished University Scholar, University of Louisville School of Medicine

Structure-based drug design at the JG Brown Cancer Center
John Trent, Ph.D., Deputy Director, Basic and Translational Research, James Graham Brown Cancer Center, Wendell Cherry Endowed Chair for Cancer Translational Research, Kosair Charities Pediatric Oncology Research Program, Professor, Department of Medicine, University of Louisville

Transcriptomic and proteomic profiling of HIV seropositive and seronegative diffuse large B-cell lymphoma
Samantha Kendrick, Ph.D., Assistant Professor, Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences

Characterization of a Y chromosome family of lncRNAs and their importance in the response of male non-small cell lung cancer cells to ionizing radiation
Ivan Martinez, Ph.D., Associate Professor, West Virginia University Cancer Institute Research Laboratories, Assistant Professor, Microbiology, Immunology & Cell Biology, West Virginia University

The Nicotinic Acetylcholine Receptor Modulator 4R as a Treatment for Non-Small Cell Lung Carcinoma
Elizabeth Castro Rivera, Cell & Molecular Biology Ph.D. Candidate, Universidad Central del Caribe, Puerto Rico

Flash Talks

The DNA methylation signature of EpCAM-/CD49f- breast cancer stem cells reveals a propensity towards an inflammation expression signature and worse overall clinical severity in basal-like breast cancers.
Austin Shull, P.D., Assistant Professor of Biology, Presbyterian College

Liver tumor-derived small extracellular vesicles modulate macrophage function
Joshua L. Hood M.D., Ph.D., Assistant Professor, Department of Pharmacology and Toxicology, University of Louisville

Gastrointestinal tract dysbiosis enhances distal tumor progression through suppression of leukocyte trafficking
Ruud P.M. Dings, Ph.D., M.SC., Assistant Professor, University of Arkansas for Medical Sciences

Establishment of Human DCLK1 Isoform 2 Isogenic Cells Using HCT116 Cells
Valeria Campbell Brown, Tougaloo College, Mississippi

Modified Michael Addition Leads to Biologically Significant
Michael Humphrey, Lyon College, Arkansas

The Role of Metadherin in Inflammatory Breast Cancer
Gabriela Ortiz-Soto, Universidad Central del Caribe-School of Medicine, Puerto Rico

Mole Detection and Tracking for Total Body Photography
Mehmet Sait Alpaydin, University of Central Arkansas

Attenuating inflammatory mediator production by AMˊL cells using normal human plasma-derived extracellular vesicle subtypes
Jeremy B. Jones, University of Louisville

McCreary
9:30 - 11:00 am Session 2: IDeA States Pediatric Clinical Trials Network Description

Co-Chairs
Janice Sullivan, M.D., Professor, Vice Chair for Research, Dept of Pediatrics, Medical Director, Kosair Charities Pediatric Clinical Trials Unit, Kentucky-Pediatric IDeA Research Center M-PI, University of Louisville
Sara Watson, M.D., Assistant Professor of Pediatrics, Division of Pediatric Endocrinology, Kentucky-Pediatric IDeA Research Center M-PI, University of Louisville
Keynote Speaker
ISPCTN: A Great New Opportunity
Sara Watson, MD, University of Louisville
Short Talks
Why Clinical Trtials are Essential to Improving Healthcare
Jessica Snowden, MD., University of Arkansas for Medical Sciences
Additional to be determined from abstract submissions.
Flash Talks
To be determined from abstract submissions.
Taylor
9:30 - 11:00 am Session 3: Data Science Description

Chair
Arnold Stromberg, PhD, Allen-Anderson Endowed Professor in Statistics, Department of Statistics, University of Kentucky
Keynote Speaker
Leveraging the Census Data Center for Biomedical Research
Matthew H. Ruther, PhD, Associate Professor of Urban and Public Affairs, Director, Kentucky State Data Center, University of Louisville
Presenter
Beckman
11:00 am- 12:30 pm Concurrent Session C
11:00 am- 12:30 pm Session 1: IDeA National Resource for Proteomics: Designing and Troubleshooting Proteomics Experiments  Description

Chair
Alan Tackett, Ph.D., Professor of Biochemistry & Molecular Biology, Scharlau Family Endowed Chair in Cancer Research, University of Arkansas for Medical Sciences
Presenters
Alan Tackett, Ph.D., Professor of Biochemistry & Molecular Biology, Scharlau Family Endowed Chair in Cancer Research, University of Arkansas for Medical Sciences
Ricky D Edmondson, PhD, Associate Professor of Medicine, Co-director, Proteomics Core Laboratory, University of Arkansas for Medical Sciences
Sam Mackintosh, Ph.D., Associate Professor, Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
Mike Kinter, Ph.D., Associate Member, Aging and Metabolism Research Program, Oklahoma Medical Research Foundation
Stephanie Byrum, Ph.D., Assistant Professor, Department of Biochemistry and Molecular Biology, Director of Systems Biology Bioinformatics Core at Arkansas Children's Research Institute, University of Arkansas for Medical Sciences
11:00 am- 12:30 pm Session 2: NRMN and IDeA Partnership for Mentorship and Networking Description

Presenters
Jamboor K. Vishwanatha, Ph.D., Regents Professor and Vice President, Principal Investigator, National Research Mentoring Network-Resource Center, Director, Texas Center for Health Disparities, Center for Diversity and International Programs, University of North Texas Health Science Center
Damaris Javier, M.A., Associate Director, Program Management, National Research Mentoring Network-Resource Center, University of North Texas Health Science Center
McCreary
12:30 - 2:30 pm Lunch and Presentations

IDeA Program Update
Ming Lei, Ph.D., Director, Division for Research Capacity Building, NIGMS, NIH
IDeA Post Award Management
Samantha Farrell, MHS, Grants Management Specialist, NIGMS, NIH
National Updates on NAIPI and NISBRE
Doug Wright, PhD, Professor and Vice Chair, Anatomy and Cell Biology, Vice Chair of Research, Anesthesiology, University of Kansas Medical Center, Director of the NIH Kansas INBRE Program, President, NAIPI
Archibald Ballroom
2:30 - 4:00 pm Concurrent Sessions D
2:30 - 4:00 pm Session 1: The Impact of the Environment on Cardiovascular Health and Disease Description

Chair
Steven P. Jones, PhD, FAHA, Professor of Medicine and University Scholar, Director, Diabetes and Obesity Center University of Louisville
Keynote Speaker
Air Pollution and Cardiovascular Disease: Insights from Cells to Animals to Patients
Sanjay Rajagopalan, MD, FACC, FAHA, Chief, Cardiovascular Medicine, University Hospitals Harrington Heart & Vascular Institute, Director, Case Cardiovascular Research Institute, Herman K. Hellerstein MD, Professor of Cardiovascular Research, Professor, Department of Internal Medicine, Case Western Reserve University

Short Talks

Electronic cigarettes and heat-not-burn cigarettes induce similar vasoconstriction as tobacco cigarettes
Mark Olfert, Ph.D., RRT, FAHA, Associate Professor, Department of Human Performance, Exercise Physiology, West Virginia University

Exposure to air pollution is associated with an altered metabolic state in mouse plasma
Benjamin Rood, B.S., University of Louisville

Beckman
2:30 - 4:00 pm Session 2: IDeA Program Infrastructure for Clinical and Translational Research (IDeA-CTR) Description

Chair
Sally Hodder, MD, West Virginia Clinical and Translational Science Institute
Presenters
Childhood Fasting Plasma Glucose and Brain Health Indicators at Midlife: Evidence from the Bogalusa Heart Study
Lydia A. Bazzano, MD, PhD, MPH, Lynda B. and H. Leighton Steward Professor in Nutrition Research, Director, Center for Lifespan Epidemiology Research, Tulane University School of Public Health and Tropical Medicine
Stephanie Broyles, PhD, Associate Professor, Director Contextual Risk Factors Laboratory, Pennington Biomedical Research Center
Taylor
 2:30 - 4:00 pm Session 3. Advances in Neuroscience Research Description

Chair
Martha Bickford, Ph.D., Professor of Anatomical Sciences and Neurobiology, Associate Director, Kentucky-IDeA Networks of Biomedical Research Excellence, University of Louisville

Keynote Speaker

Proteostasis as a global therapeutic target for CNS injury
Scott R. Whittemore, Ph.D., Professor and Vice Chairman for Research, Department of Neurological Surgery, Henry D. and Marianna Garretson Endowed Chair in Spinal Cord Injury Research Scientific Director, Kentucky Spinal Cord Injury Center, University of Louisville

Short talks

Effects of early-life antipsychotic administration on striatal nicotine receptor density in adulthood
Mark E. Bardgett, Ph.D., Regents Professor, Department of Psychology, Northern Kentucky University

Sympathetic regulation of inflammatory response to sleep fragmentation
Noah T. Ashley, Ph.D., Lancaster Professor, Associate Professor, Department of Biology, Western Kentucky University

Flash Talks

Zika Virus infection and its effect on the CREB3L1 pathway
Joaris Soto-Hernandez, Ponce Health Sciences University, Puerto Rico

Differentially expressed genes after adolescent intermittent ethanol exposure
Riya Patel, Marshall University, West Virginia

The role of matrix metalloproteinases in the metabolism of ATXN1 protein aggregates
Desiree-Gift Mills, Tougaloo College, Mississippi

Neurotrophin-independent p75NTR Processing is Facilitated by c-Jun N-terminal Kinase in Dopaminergic Cells Subjected to Oxidative Stress
Rachel Clements, Eastern Kentucky University

McCreary
4:00 - 6:00 pm Poster Session I, Group A Cochran Ballroom
6:30 pm Dinner and Presentations

The NIH Common Fund: Funding Opportunities for Exceptionally Innovative Research
Ravi Basavappa, Ph.D., Program Leader, High-Risk High-Reward Research Program, Office of Strategic Coordination (The Common Fund Office), Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH
CUR – Who we are and How we can help you achieve INBRE’s goals
Paula Dehn, PhD, Council of Undergraduate Research, Kentucky Weslyan College
Research Evaluation and Commercialization Hubs (REACH) in Kentucky: Lessons learned and future opportunities
Paula J. Bates, Ph.D., Professor of Medicine, University of Louisville, Co-Director, ExCITE and KYNETIC Programs
Archibald Ballroom
8:00 - 10:00 pm Setup – Poster Session II, Group B Cochran Ballroom
FRIDAY, NOVEMBER 8, 2019
7:30 am - 2:00 pm 11:00 AM check-out deadline Hotel Check-out
7:30 - 11:00 am Registration Desk Hours of Operation West/Rivue Tower, 3rd Floor
7:30 - 8:30 am Continental Breakfast Archibald Ballroom
7:30 - 8:30 am Student Breakfast

Preparing students for a broad range of careers
Nathan L. Vanderford, Ph.D., MBA, Assistant Professor, Department of Toxicology and Cancer Biology, Assistant Director for Research, Markey Cancer Center, Director of Administration, Center for Cancer and Metabolism, Director, Appalachian Career Training in Oncology Program
Daisy
7:30 - 8:30 am INBRE PI Breakfast Cafe Magnolia
8:30 - 10:30 am Poster Session II, Group B Cochran Ballroom
10:30 am - 12:00 pm Concurrent Session E
10:30 am - 12:00 pm Session 1: Entrepreneurship/Commercialization HUB - XLerateHealth  Description

Chair
Jackie Willmot, RN, MSN, MBA, CEO and Co-Founder, XLerateHealth

Panel

Bob Saunders, Chairman and Co-Founder, XLerateHealth.

Eugene Krentsel, Ph.D., Chief Scientific Officer and Vice President for Strategic Partnerships and Alliances at XLerateHealth

Brett Janis, PhD candidate, University of Louisville and Co-Founder, Desicorp

Taunya Phillips, MBA, Senior Associate Director,  New Ventures & Alliances Office of Technology Commercialization, Co-investigator

Lily
10:30 am - 12:00 pm Session 2: Writing the R-Series NIH Grant Application  Description

Presenter
Kathy Doyle Grzech, M.A., Executive Director, Proposal Development Office, University of Kentucky
Daisy
12:00 - 2:00 pm Lunch and Awards Ceremony Archibald Ballroom
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